GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6911965 | 1 | rs61280878 | chr6:24468741 | GMNN | chr6:24775159-24786276:+ | -0.28 | -3.81 | 0.000159 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs61280878 | chr6:24468741 | GPLD1 | chr6:24428405-24489850:- | 0.25 | 4.7 | 3.49E-6 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs61280878 | chr6:24468741 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.47 | 7.34E-8 | Hematological and biochemical traits |
| THCA | cis | rs12435908 | 1 | rs61315421 | chr14:66076603 | LOC645431 | chr14:65877313-65879335:- | -0.61 | -7.61 | 1.43E-13 | Ischemic stroke |
| THCA | cis | rs16958440 | 1 | rs61316646 | chr18:44610670 | HDHD2 | chr18:44633782-44676871:- | 0.35 | 6.36 | 4.71E-10 | Sitting height ratio |
| THCA | cis | rs2129782 | 1 | rs61320020 | chr8:89414644 | MMP16 | chr8:89049462-89339717:- | 0.32 | 5.1 | 4.9E-7 | Electrodermal activity |
| THCA | cis | rs6138150 | 1 | rs6132678 | chr20:23842323 | CST5 | chr20:23856572-23860380:- | 0.13 | 3.42 | 0.000685 | Response to TNF antagonist treatment |
| THCA | cis | rs6138150 | 1 | rs6132679 | chr20:23842400 | CST5 | chr20:23856572-23860380:- | 0.13 | 3.42 | 0.000685 | Response to TNF antagonist treatment |
| THCA | cis | rs7267979 | 1 | rs6132835 | chr20:25434667 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -6.86 | 2.2E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6132835 | chr20:25434667 | FAM182A | chr20:26035250-26067552:+ | -0.18 | -3.39 | 0.000749 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6132835 | chr20:25434667 | FAM182B | chr20:25744102-25848786:- | 0.26 | 5.32 | 1.6E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6132835 | chr20:25434667 | NINL | chr20:25433338-25566153:- | -0.35 | -7.17 | 2.81E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6132835 | chr20:25434667 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.73 | 0.000215 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs965469 | 1 | rs6133036 | chr20:3349682 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.87 | 8.09E-9 | IFN-related cytopenia |
| THCA | cis | rs7223966 | 1 | rs61360320 | chr17:61800392 | FTSJ3 | chr17:61896795-61905031:- | 0.3 | 5.78 | 1.32E-8 | Body mass index |